A Potential application of Colonic drug delivery system in prevention and treatment of Colorectal Cancer

Colonic drug delivery system in prevention and treatment of Colorectal Cancer



  • Mudassir Ansari Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS University, Mumbai, India. https://orcid.org/0000-0001-7440-7709
  • Kavita Singh Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management


Colorectal cancer, pH sensitive system, microbial triggered system, pH and microbial triggered system, pH and time dependent system, bioadhesive system.


Colorectal cancer (CRC) is the second leading cause of cancer related deaths in USA. The current regimen used to treat colorectal cancer has many side effects and have higher drug distribution in other tissues. Physical activity and diet play major role in prevention of Colon cancer which is briefly discussed in this paper. Colon targeted drug delivery system (CoDDS) is found to be a promising approach to target the drug specifically to colon. This review provides the description of various colon targeted approaches that can be used to treat CRC. Factors to be consider while designing CoDDS include pH of GIT, Transit time of GI tract and Microbiota of colon. This review will discuss the staging and standard treatments modalities for CRC.


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Adenoma carcinoma sequence and the target for chemoprevention



How to Cite

Ansari, M., & Singh, K. (2021). A Potential application of Colonic drug delivery system in prevention and treatment of Colorectal Cancer: Colonic drug delivery system in prevention and treatment of Colorectal Cancer. The Journal of Pharmaceutical Sciences and Medicinal Research, 1(03), 045–060. https://doi.org/10.53049/tjopam.2021.v001i03.011